Deathblow or Death Blow may refer to:
- death blow
- Coup de grace
- Dissecting aortic aneurysm
- Deathblow (comics) is a fictional character in the Wildstorm Universe
- "Death Blow" is a fictional movie in the Seinfeld episode "The Little Kicks"
- A song by the alternative metal band Deftones included in their fourth studio album.